Diagnostic Information
Clinical Applications


At the LCL, we are interested in understanding i) the different cognitive mecanisms in reading, 2) the neural underpining of these mecanisms and 3) the constraints that imposes the visual ssytem on reading. All all those aspect are explored using fMRI and MEEG. Our most current work involves the coresgistration in real time of eye movement and EEG during sentence reading.

A nice exemple of fMRI research is given by Levy et al 2009. In this experiment, we presented various stimuli from single charaters to full words. Stimuli varied from known to unknown and in complexity. Using Structural equation modeling, we showed that the dual route cascade model is somehow supported by fMRI data. The lexical route (word reading) led to a classical link between the infero-temporal cortex (VWFA) and the frontal cortex (IFG), although there were evidence that information is also send to the lateral parietal cortex (Angular, SMG?). However, the surprise was that the indirect route (for pseudoword) involves a step via the VWFA before transitting to the lateral parietal and frontal cortex.



Left Panel: Group trade-off between preferences (delta values) for the word pathway vs. the pseudoword pathway resulting in efficient (dark-red) or deficient (yellow-green) reading performance outside the scanner (CTL index). Right Panel: Subjects with nonconformist reading styles during word (blue) and pseudoword (red) reading which predict their highly-efficient (subject 15) and inefficient (subject 2) reading performance.